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1 April 2004 Molecular Characterization of Low Pathogenicity H7N3 Avian Influenza Viruses Isolated in Italy
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Abstract

The complete coding regions of the surface glycoproteins, nucleoprotein (NP), polymerase 2 (PB2), and matrix (M) of A/turkey/214845/02 and A/turkey/220158/99 (H7N3) low pathogenicity avian influenza (LPAI) viruses isolated in October 2002 in Italy were amplified and sequenced to determine the epidemiologic relationships with an A/turkey/Italy/4603/99 (H7N1/4603/99) LPAI virus isolated during the 1999–2001 epizootic in Italy. The hemagglutinin (HA) of H7N3 viruses showed 97.8% nucleotide similarity with A/turkey/Italy/4603/99 (H7N1), and NP, M, and PB2 gene similarities were 93.6%, 98.2%, and 96.2%, respectively. Phylogenetic analyses of HA, PB2, and M genes showed that H7N3 and H7N1 viruses were closely related. Sequence analysis revealed a 23 amino acid deletion in the stalk of the neuraminidase of H7N3 viruses and a unique deletion of amino acid glycine in position 17 in the NP gene of H7N1 virus.

L. Di Trani, B. Bedini, P. Cordioli, M. Muscillo, E. Vignolo, A. Moreno, and M. Tollis "Molecular Characterization of Low Pathogenicity H7N3 Avian Influenza Viruses Isolated in Italy," Avian Diseases 48(2), 376-383, (1 April 2004). https://doi.org/10.1637/7088
Received: 14 July 2003; Published: 1 April 2004
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