Seventy-four lichen species, identified from both modern and historical vouchers, are reported for Lizard Lick, Wake County, North Carolina. Like many granite flat rock areas in the southeastern United States, the Lizard Lick flora is a unique combination of Piedmont and Coastal Plain species. The Lizard Lick lichen flora shares 24 species in common with two similar, nearby granite flat rock sites, Temple Flat Rock Preserve and Turnipseed Nature Preserve. Species characteristic of granite flat rock habitats were found, including Peltula cylindrica and Pyrenopsis portoricensis; the latter collection represents the second record of this species for North America.