The aim of this study was to evaluate the performance of Patagonian octopus fed with moist diets formulated with several local feed ingredients. All formulated diets were based on crab paste (70%) and the experimental feed ingredient (30%). Experiment 1 assayed salmon meal, prime sardine meal, and wheat gluten, using fresh fish as a control; experiment 2 assayed prime fish meal and macroalgal meal against crab paste alone as a control. The ingestion rate was lower than expected for all diets except those of fresh fish, crab paste alone, and crab paste plus prime sardine meal. No significant differences were found in the observed digestibility of the diets, indicating, in general, low digestibility, even for fresh fish. The highest protease values were observed for crab paste plus prime sardine meal in both experiments. The better growth of Enteroctopus. megalocyathus was obtained when these were fed fresh fish, which was associated with the greater consumption observed in this diet, as neither the digestibility nor the enzymatic activities of the hepatopancreas were related to this greater growth.