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1 March 2008 Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance
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Oral Tolerance is the temporary loss of systemic immunological responsiveness to a specific soluble antigen after ingestion of that antigen. Results from our lab and others indicated that CTLA-4 and lack of IL-12 played a role in the induction of low dose oral tolerance at the Th1 cell level. Previous literature suggested that IL-18 also played a role in preventing oral tolerance induction while the cytokine IL-10 had been shown to be a factor contributing to suppressed immune responses. To determine the role of CTLA-4 in conjunction with either IL-18 or IL-10 in low dose oral tolerance induction, anti-CTLA-4 mAb and either IL-18 or anti-IL-10 mAb were administered concurrently to mice fed either ovalbumin (OVA) or water. Results showed that the PLN cell proliferation of mice treated with anti-CTLA-4 mAb and IL-18 remained significantly suppressed compared with water-fed controls, while a partial abrogation of suppressed IL-4 and IFN-γ levels were observed. In contrast, mice treated with anti-CTLA-4 mAb and anti-IL-10 mAb exhibited a reversal of PLN cell proliferation and IL-4 suppression; however, IFN-γ levels remained suppressed. Results suggest that IL-10, IL-18 and CTLA-4 play roles in the induction of oral tolerance at the cell proliferation and cytokine level.

Kathleen Siobhan Barone, Rachael Burns, Stephanie Horton, Armando Retana, Lindsey Jackson Meredith Wall, and Tifany Nolan "Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance," Journal of the Kentucky Academy of Science 69(1), 11-18, (1 March 2008).[11:ROCIAI]2.0.CO;2
Published: 1 March 2008

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