Translator Disclaimer
1 June 2001 Cooperative Phenomena in Two-pulse, Two-color Laser Photocoagulation of Cutaneous Blood Vessels
Author Affiliations +
Abstract

A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation and in vitro, using cuvettes of whole or diluted blood. The system permits sequenced irradiation with well-defined intrapulse spacing at 532 nm, using a long-pulse frequency-doubled Nd:YAG laser, and at 1064 nm, using a long-pulse Nd:YAG laser. Using this system, we have identified a parameter space where two pulses of different wavelengths act in a synergistic manner to effect permanent vessel damage at radiant exposures where the two pulses individually have little or no effect. Using a two-color pump–probe technique in vitro, we have identified a phenomenon we call green-light–induced infrared absorption, where a pulse of green light causes photochemical and photothermal modifications to the chemical constituents of blood and results in enhanced infrared absorption. We identify a new chemical species, met-hemoglobin, not normally present in healthy human blood but formed during laser photocoagulation which we believe is implicated in the enhanced near-infrared absorption.

Jennifer Kehlet Barton, George Frangineas, Herbert Pummer, and John F. Black "Cooperative Phenomena in Two-pulse, Two-color Laser Photocoagulation of Cutaneous Blood Vessels," Photochemistry and Photobiology 73(6), 642-650, (1 June 2001). https://doi.org/10.1562/0031-8655(2001)073<0642:CPITPT>2.0.CO;2
Received: 10 October 2000; Accepted: 1 February 2001; Published: 1 June 2001
JOURNAL ARTICLE
9 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top