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1 December 2004 The Topical Isoflavonoid NV-07α Reduces Solar-simulated UV-induced Suppression of Mantoux Reactions in Humans
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UV radiation suppresses delayed-type hypersensitivity responses to intradermally injected tuberculin purified protein derivative in Mantoux-positive individuals. The effect of the topically administered isoflavonoid NV-07α, a synthetic derivative of the isoflavonoid equol, on UV-induced suppression of Mantoux reactions was assessed in 18 healthy Mantoux-positive volunteers. A single, fixed dose of solar-simulated UV radiation was delivered to the volunteers' lower backs. Different concentrations of NV-07α or its vehicle were applied to different sites within the irradiated field immediately after UV exposure and again 24 h later. Forty-eight hours after irradiation, Mantoux testing was performed at both the irradiated sites and adjacent, unirradiated sites. The intensity of Mantoux reactions was measured 72 h later with a reflectance erythema meter and by measuring the diameter of each reaction. Although lower concentrations of NV-07α (0.5 and 2 mM) did not prevent UV immunosuppression, 4 mM NV-07α partially but significantly attenuated UV-induced suppression of Mantoux-induced erythema. Minimal erythema doses were also determined for sites treated with NV-07α or its vehicle immediately after UV exposure. NV-07α had no significant effects on UV erythema. We conclude that 4 mM NV-07α prevented the suppressive effects of UV radiation on Mantoux responses in humans but did not affect UV-induced erythema at the concentrations used.

Adam C. Friedmann, Gary M. Halliday, Ross StC. Barnetson, Vivienne E. Reeve, Catherine Walker, Clare R. S. Patterson, and Diona L. Damian "The Topical Isoflavonoid NV-07α Reduces Solar-simulated UV-induced Suppression of Mantoux Reactions in Humans," Photochemistry and Photobiology 80(3), 416-421, (1 December 2004).<0416:TTINRS>2.0.CO;2
Received: 18 August 2004; Accepted: 1 August 2004; Published: 1 December 2004

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