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1 December 2004 Ship-in-a-Bottle Synthesis of Fluorescence-labeled Nanoparticles: Applications in Cellular Imaging
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Abstract

Fluorescein (2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid) has been prepared inside the pores of zeolite-Y via ship-in-a-bottle synthesis. Fluorescein, whose dimensions prevent it from entering through the ∼7 Å windows of the faujasite zeolite used, was prepared by the acid-catalyzed reaction of resorcinol and phthalic anhydride. In this article we report initial spectroscopic data as well as an example of the usefulness of these fluorescence-labeled nanoparticles for imaging applications such as confocal fluorescence microscopy. Encapsulated fluorescein shows a remarkable increase in photostability.

Michelle N. Chrétien, Biao Shen, Hermenegildo García, Ann M. English, and J. C. Scaiano "Ship-in-a-Bottle Synthesis of Fluorescence-labeled Nanoparticles: Applications in Cellular Imaging," Photochemistry and Photobiology 80(3), 434-437, (1 December 2004). https://doi.org/10.1562/0031-8655(2004)080<0434:SSOFNA>2.0.CO;2
Received: 6 June 2004; Accepted: 1 September 2004; Published: 1 December 2004
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