Translator Disclaimer
1 September 2005 Choice of Optimal Wavelength for PDT: The Significance of Oxygen Depletion
Author Affiliations +
Abstract

We have investigated the role of tissue oxygenation on light penetration into tissue at different wavelengths. As a field of application we have chosen aminolevulinic acid–photodynamic therapy (ALA-PDT). To calculate efficiency spectra of PDT on human skin one needs to know the excitation spectrum of the photosensitizer of interest and the relative fluence rate as a function of depth in the tissue. We measured the former and computed the latter with an accurate radiative transfer algorithm. In this way we determined the efficiency spectra as functions of depth for different types of basal cell carcinomas (BCC). Our results suggest that ALA-PDT works best for nodular BCC at a wavelength of 630 nm, whereas it works best for pigmented superficial BCC at a wavelength of 390 nm. At 630 nm the light penetration into a tumor depends strongly on the oxygenation of the blood. Below a 2 mm thick, well-oxygenated, nodular BCC, we find the efficiency to be an order of magnitude larger than below a poorly oxygenated tumor. At 390 nm, the light penetration into a tumor does not depend on the oxygenation of the blood.

Kristian P. Nielsen, Asta Juzeniene, Petras Juzenas, Knut Stamnes, Jakob J. Stamnes, and Johan Moan "Choice of Optimal Wavelength for PDT: The Significance of Oxygen Depletion," Photochemistry and Photobiology 81(5), 1190-1194, (1 September 2005). https://doi.org/10.1562/2005-04-06-RA-478
Received: 6 April 2005; Accepted: 1 May 2005; Published: 1 September 2005
JOURNAL ARTICLE
5 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top