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1 November 2005 Spectral Properties of Pro-multimodal Imaging Agents Derived from a NIR Dye and a Metal Chelator
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Abstract

Monomolecular multimodal imaging agents (MOMIAs) are able to provide complementary diagnostic information of a target diseased tissue. We developed a convenient solid-phase approach to construct two pro-MOMIAs (before incorporating radiometal) derived from 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and cypate, a near-infrared (NIR) fluorescent dye analogous to indocyanine green (ICG). The possible interaction between d orbitals of transition metal DOTA complexes or free metals and the p orbitals of cypate chromophore could quench the fluorescence of pro-MOMIAs. However, we did not observe significant changes in the spectral properties of cypate upon conjugation with DOTA and subsequent chelation with metals. The fluorescence intensity of the chelated and nonmetal-chelated PRO-MOMIAs remained fairly the same in dilute 20% aqueous dimethylsulfoxide (DMSO) solution (1 × 10−6 M). Significant reduction in the fluorescence intensity of pro-MOMIAs occurred in the presence of a large excess of metal ions (>1 molar ratio for indium and 20-fold for a copper relative to pro-MOMIA). This study suggests the feasibility of using MOMIAs for combined optical and radioisotope imaging.

Zongren Zhang and Samuel Achilefu "Spectral Properties of Pro-multimodal Imaging Agents Derived from a NIR Dye and a Metal Chelator," Photochemistry and Photobiology 81(6), 1499-1504, (1 November 2005). https://doi.org/10.1562/2005-06-08-RA-568
Received: 8 June 2005; Accepted: 1 August 2005; Published: 1 November 2005
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