Xanthones with amino substituents were synthesized to diminish the photoreactivity of the xanthone chromophore with DNA, with the objective of using these molecules to study their binding dynamics with DNA. The aminoxanthones showed a strong solvatochromic effect on their singlet and triplet excited-state photophysics, where polar solvents led to a decrease of the energies for the excited states. Quenching of the triplet excited states by nitrite anions was used to determine the binding dynamics, and a residence time in the microsecond time domain was estimated for the bound 2-aminoxanthone with DNA. The quenching experiments performed showed that this methodology will not be applicable to study the binding dynamics of a wide variety of guests with DNA.
How to translate text using browser tools
1 January 2006
Photophysics of Aminoxanthone Derivatives and Their Application as Binding Probes for DNA
Tamara C. S. Pace,
Sarah L. Monahan,
Andrew I. MacRae,
Monica Kaila,
Cornelia Bohne
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Photochemistry and Photobiology
Vol. 82 • No. 1
January 2006
Vol. 82 • No. 1
January 2006