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1 November 2006 New Insights into Lung Surfactant Monolayers Using Vibrational Sum Frequency Generation Spectroscopy
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Abstract

At the air–water interface, interfacial molecular structure, intermolecular interactions, film relaxation and film respreading of model lung surfactant monolayers were studied using vibrational sum frequency generation (VSFG) spectroscopy combined with a Langmuir film balance. Chain-perdeuterated dipalmitoylphosphatidylcholine (DPPC-d62), palmitoyloleoylphosphatidylglycerol (POPG), palmitic acid (PA) and tripalmitin were investigated. In the DPPC-d62–PA binary monolayer, PA showed a condensing effect on the DPPC chains. On the contrary, in the DPPC-d62–POPG binary monolayer, POPG showed a fluidizing effect on the DPPC chains. In the ternary monolayer system of DPPC-d62–POPG–PA, the balance between the fluidizing and the condensing effect was also observed. In addition, the film relaxation behavior of DPPC-d62 and the enhanced film stability of DPPC-d62 caused by the addition of tripalmitin were observed. Real-time VSFG was also employed to study the respreading properties of a complex lung surfactant mixture containing DPPC-d62, POPG, PA and KL4 (a mimic of SP-B) peptide, which revealed DPPC enrichment after film compression.

Gang Ma and Heather C. Allen "New Insights into Lung Surfactant Monolayers Using Vibrational Sum Frequency Generation Spectroscopy," Photochemistry and Photobiology 82(6), 1517-1529, (1 November 2006). https://doi.org/10.1562/2006-06-30-IR-958
Received: 30 June 2006; Accepted: 1 August 2006; Published: 1 November 2006
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