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1 November 2006 Intrinsic Fluorescence Polarization of Amniotic Fluid: II. Toward a Noninvasive Method for the Determination of Fetal Lung Maturity
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Abstract

The present study compares two methods for the determination of fetal lung maturity: the novel intrinsic fluorescence polarization ratio (IFPR) and the commercial TDx-FLMII. Amniotic fluid (AF) samples were collected from 69 women during the second and third trimesters of singleton pregnancies. Thirty-three samples were tested for IFPR only after centrifugation, and the rest were examined both before and after centrifugation. Of the latter 33 samples, 29 were assessed for lung maturity with the TDx-FLMII method as well. The results showed that IFPR values decreased with the advance in gestational age (r = 0.77, p < 0.05, n = 69). A significant correlation was found between IFPR of centrifuged and noncentrifuged samples (r = 0.94, p < 0.05, n = 36). A significant correlation was demonstrated between IFPR and TDx-FLMII values of centrifuged (r = 0.75, p < 0.05, n = 29) and noncentrifuged (r = 0.63, p < 0.05, n = 29) samples and moreover, samples considered mature by TDx-FLMII had low values of IFPR (n = 10). It can be concluded that the IFPR method can utilize noncentrifuged AF, thus suggested as a potential noninvasive method.

Hemy Avraham, Eric Ohana, Eli Maymon, Rivka Cohen-Luria, Jonathan Molcho, and Abraham H. Parola "Intrinsic Fluorescence Polarization of Amniotic Fluid: II. Toward a Noninvasive Method for the Determination of Fetal Lung Maturity," Photochemistry and Photobiology 82(6), 1591-1594, (1 November 2006). https://doi.org/10.1562/2006-07-27-RA-986
Received: 27 July 2006; Accepted: 1 August 2006; Published: 1 November 2006
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