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1 October 2006 Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams
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Abstract

Kase, Y., Kanai, T., Matsumoto, Y., Furusawa, Y., Okamoto, H., Asaba, T., Sakama, M. and Shinoda, H. Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams. Radiat. Res. 166, 629–638 (2006).

The microdosimetric spectra for high-energy beams of photons and proton, helium, carbon, neon, silicon and iron ions (LET = 0.5–880 keV/μm) were measured with a spherical-walled tissue-equivalent proportional counter at various depths in a plastic phantom. Survival curves for human tumor cells were also obtained under the same conditions. Then the survival curves were compared with those estimated by a microdosimetric model based on the spectra and the biological parameters for each cell line. The estimated α terms of the liner-quadratic model with a fixed β value reproduced the experimental results for cell irradiation for ion beams with LETs of less than 450 keV/μm, except in the region near the distal peak.

Yuki Kase, Tatsuaki Kanai, Yoshitaka Matsumoto, Yoshiya Furusawa, Hiroyuki Okamoto, Toru Asaba, Makoto Sakama, and Hiroshi Shinoda "Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams," Radiation Research 166(4), 629-638, (1 October 2006). https://doi.org/10.1667/RR0536.1
Received: 5 January 2006; Accepted: 1 June 2006; Published: 1 October 2006
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