Five new species of aeolid nudibranchs are described based on specimens collected at several localities of the tropical eastern Pacific, from Isla Isabela, Nayarit, Mexico to Parque Nacional de Coiba, Panama. Three of the new species belong to the genus Cuthona Alder and Hancock, 1855, one to Eubranchus Forbes, 1838, and one to Cerberilla Bergh, 1873. All are distinct from other previously known species of these genera. An additional species, possibly belonging to the genus Herviella Baba, 1949 is not named because of the lack of adequate anatomical information.