A new genus, Reductoonops, is established for a group of New World soft-bodied oonopine spiders, found from Mexico south to Chile, characterized by reduced size, a flattened clypeus, loss of the posterior median spinnerets, and often by loss of the four posterior eyes. Members of this group resemble those of Stenoonops Simon but lack the clump of short setae found on the dorsal surface of the palpal tarsus of both sexes in that genus, and often have four pairs of deep channels at the sides of the sternum, the most anterior pair of which demarcate a short, trapezoidal, anterior portion of the sternum. A total of 34 new species are described from Mexico (chamela, armeria, niltepec, real, nubes, jabin), Costa Rica (monte, lucha), Costa Rica and Panama (naci), Panama (almirante, escopeta, bayano), Jamaica (ferry), Curaçao (hato), Martinique (diamant), Colombia (marta, sasaima, meta, leticia), Ecuador (tandapi, pichincha, tina, domingo, otonga, palenque, napo, jatun, hedlite, molleturo, celica, yasuni), the Galapagos Islands (pinta), Peru (carpish), and Chile (elqui).