Isthmohyla insolita and Exerodonta catracha are Honduran hylids of uncertain phylogenetic relationships. In this paper we present a phylogenetic analysis of mitochondrial and nuclear genes to study their relationships. Our results show that these species are, respectively, the sister taxon of and nested among the few available species of Plectrohyla, possibly the least studied genus of Hylini in terms of phylogenetic relationships. To solve the polyphyly of Exerodonta and Isthmohyla, both species are provisionally transferred to Plectrohyla, pending a broader phylogenetic study including all species in the genus. Consequently, Isthmohyla is restricted to a group of hylids endemic to the Isthmian highlands of Costa Rica and Panama in lower Central America. The inclusion of I. insolita in Plectrohyla implies another instance of independent evolution of terrestrial egg clutches in Hylini.