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1 October 2002 Comparison of a Putative Second Serotype of Chicken Infectious Anemia Virus with a Prototypical Isolate I. Pathogenesis
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Abstract

CIAV-7 is a virus with similar pathogenic and physicochemical characteristics to, but antigenically distinct from, chicken infectious anemia virus (CIAV). The pathogenesis of CIAV-7 was evaluated in a comparative study with a representative isolate of CIAV, the Del-Ros strain. The pathogenesis of CIAV-7 was similar to Del-Ros on the basis of the clinical disease induced and gross and microscopic lesions, although CIAV-7 produced fewer and less severe lesions overall. A second comparative pathogenesis study was performed with Del-Ros and CIAV-7, both alone and in combination with infectious bursal disease virus (IBDV). In this study, the pathogenesis of CIAV-7 was similar to Del-Ros in clinical, gross, and microscopic lesions in the bone marrow. However, thymic lesions were less severe in CIAV-7–inoculated birds. The interaction between Del-Ros and IBDV was synergistic, whereas there was no observed potentiation of CIAV-7–induced disease by IBDV. Progeny from breeder flocks from several geographic locations in the eastern United States were challenged with CIAV-7 or Del-Ros to assess protection by maternal antibodies. Some progeny from all flocks had protection against CIAV-7 challenge, providing evidence for the presence of CIAV-7 in the field. Additionally, the number of birds protected against CIAV-7 or Del-Ros challenge varied within flocks, demonstrating that the agents are serologically distinct.

E. Spackman, S. S. Cloud, C. R. Pope, and J. K. Rosenberger "Comparison of a Putative Second Serotype of Chicken Infectious Anemia Virus with a Prototypical Isolate I. Pathogenesis," Avian Diseases 46(4), 945-955, (1 October 2002). https://doi.org/10.1637/0005-2086(2002)046[0945:COAPSS]2.0.CO;2
Received: 9 April 2002; Published: 1 October 2002
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