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29 June 2022 Expression patterns and the roles of phosphatidylinositol phosphatases in testis
Yasemin Ceyhan, Manqi Zhang, Carlos G. Sandoval, Alexander I. Agoulnik, Irina U. Agoulnik
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Abstract

Phosphoinositides (PIs) are relatively rare lipid components of the cellular membranes. Their homeostasis is tightly controlled by specific PI kinases and PI phosphatases. PIs play essential roles in cellular signaling, cytoskeletal organization, and secretory processes in various diseases and normal physiology. Gene targeting experiments strongly suggest that in mice with deficiency of several PI phosphatases, such as Pten, Mtmrs, Inpp4b, and Inpp5b, spermatogenesis is affected, resulting in partial or complete infertility. Similarly, in men, loss of several of the PI phosphatases is observed in infertility characterized by the lack of mature sperm. Using available gene expression databases, we compare the expression of known PI phosphatases in various testicular cell types, infertility patients, and mouse age-dependent testicular gene expression, and discuss their potential roles in testis physiology and spermatogenesis.

Summary Sentence

Phosphatidylinositol polyphosphate phosphatases (PI phophatases) play an important role in testicular function by regulating spermatogenesis, maintaining testicular muscle function and blood–testis barrier, and by modulating overall metabolic health.

Graphical Abstract

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© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Yasemin Ceyhan, Manqi Zhang, Carlos G. Sandoval, Alexander I. Agoulnik, and Irina U. Agoulnik "Expression patterns and the roles of phosphatidylinositol phosphatases in testis," Biology of Reproduction 107(4), 902-915, (29 June 2022). https://doi.org/10.1093/biolre/ioac132
Received: 23 March 2022; Accepted: 20 June 2022; Published: 29 June 2022
KEYWORDS
infertility
lipid phosphatases
phosphatidylinositol pathway
spermatogenesis
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