1 August 2000 GATA-2 Restricts Prolactin-Like Protein A Expression to Secondary Trophoblast Giant Cells in the Mouse
Grace T. Ma, Daniel I. H. Linzer
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An analysis of the pattern of expression of the mouse placental hormone prolactin-like protein A (PLP-A) has revealed that this hormone is expressed exclusively in secondary trophoblast giant cells but not in primary giant cells. Thus, PLP-A serves as a marker for a subset of giant cells. Recent results have indicated that PLP-A binds to and inhibits the activity of natural killer cells, and thus, the localized expression of PLP-A may be important for regulating the activity of this class of T lymphocytes in a restricted region of the implantation site. Previous studies indicated that the transcription factor GATA-2 is required for the trophoblast giant cell-specific expression of two other hormones in the prolactin family, placental lactogen I and proliferin. In the absence of GATA-2, PLP-A continues to be expressed, but in this mutant background, PLP-A mRNA is detected in both primary and secondary giant cells. Thus, GATA-2 contributes both to positive and negative regulation of trophoblast giant cell-specific gene expression, and this factor apparently plays an important role in generating or maintaining the distinct functions of secondary, compared with primary, trophoblast giant cells.

Grace T. Ma and Daniel I. H. Linzer "GATA-2 Restricts Prolactin-Like Protein A Expression to Secondary Trophoblast Giant Cells in the Mouse," Biology of Reproduction 63(2), 570-574, (1 August 2000). https://doi.org/10.1095/biolreprod63.2.570
Received: 13 January 2000; Accepted: 1 March 2000; Published: 1 August 2000
developmental biology
gene regulation
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