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1 October 2005 Adrenomedullin Enhances Invasion by Trophoblast Cell Lines
Xiaoquan Zhang, Kortney E. Green, Chandra Yallampalli, Yuan Lin Dong
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We have tested the hypothesis that adrenomedullin (ADM), a multifunctional peptide hormone, works as a trophoblast proinvasion factor. Our results showed that ADM receptor components—the mRNA and proteins of calcitonin receptor-like receptor (CALCRL) and receptor activity modifying proteins (RAMPs)—were expressed by human choriocarcinoma JAr cells and first-trimester cytotrophoblast HTR-8/SV neo cells. ADM stimulates both JAr and HTR-8/SV neo cell proliferation. The invasion capabilities of JAr cells and HTR-8/SV neo cells were also enhanced by ADM, and this was associated with increased gelatinolytic activity and reduced plasminogen activator inhibitor-1 mRNA expression (SERPINE1). Our data support the notion that ADM may be involved in the human implantation process via regulating trophoblast proliferation and differentiation.

Xiaoquan Zhang, Kortney E. Green, Chandra Yallampalli, and Yuan Lin Dong "Adrenomedullin Enhances Invasion by Trophoblast Cell Lines," Biology of Reproduction 73(4), 619-626, (1 October 2005).
Received: 28 January 2005; Accepted: 1 May 2005; Published: 1 October 2005
cell proliferation
growth factors
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