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6 June 2012 The Antiapoptotic Effect of Galectin-3 in Human Endometrial Cells under the Regulation of Estrogen and Progesterone
Huan Yang, Caixia Lei, Chao Cheng, Yuzhe Feng, Wei Zhang, Rafaella Gehm Petracco, Sharif Sak
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Abstract

Galectin-3 (Gal-3), a ubiquitously expressed gene involved in many cellular processes, has been recently recognized as a factor related to endometrial receptivity. However, the precise biological function of Gal-3 in the endometrium and its regulation is still unclear. In this study, we detected the antiapoptotic role of Gal-3 in endometrial cells and the expression of Gal-3 regulated by estrogen and progesterone. We found that expression of Gal-3 increased when exposed to the apoptosis inducer staurosporine. Gal-3-silenced endometrial cells were more sensitive to the apoptosis inducer. Estradiol (E2) and progesterone (P4) up-regulated Gal-3 expression, which in turn decreased the apoptotic rate of endometrial cells. Our results strongly suggested that hormonal activation of Gal-3 by E2 and P4 is involved in inhibiting endometrial cell apoptosis, playing key roles in embryo implantation.

© 2012 by the Society for the Study of Reproduction, Inc.
Huan Yang, Caixia Lei, Chao Cheng, Yuzhe Feng, Wei Zhang, Rafaella Gehm Petracco, and Sharif Sak "The Antiapoptotic Effect of Galectin-3 in Human Endometrial Cells under the Regulation of Estrogen and Progesterone," Biology of Reproduction 87(2), (6 June 2012). https://doi.org/10.1095/biolreprod.112.099234
Received: 31 January 2012; Accepted: 1 May 2012; Published: 6 June 2012
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