Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX1

Daniel J. Bernard; Stella Tran

doi:10.1095/biolreprod.113.107797

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20 February 2013 Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX

Daniel J. Bernard, Stella Tran

Author Affiliations +

Daniel J. Bernard,^1,2,3,* Stella Tran¹

¹3Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
²4Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
³5Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

^*Correspondence: Daniel J. Bernard, Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Suite 1315, Montreal, QC, Canada. E-mail: daniel.bernard@mcgill.ca

Biology of Reproduction, 88(3): (2013). https://doi.org/10.1095/biolreprod.113.107797

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Abstract

Activins were discovered and, in fact, named more than a quarter century ago based on their abilities to stimulate pituitary follicle-stimulating hormone (FSH) synthesis and secretion. However, it is only in the last decade that we have finally come to understand their underlying mechanisms of action in gonadotroph cells. In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.

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Daniel J. Bernard and Stella Tran "Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX," Biology of Reproduction 88(3), (20 February 2013). https://doi.org/10.1095/biolreprod.113.107797

Received: 8 January 2013; Accepted: 1 February 2013; Published: 20 February 2013

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Biology of Reproduction
Vol. 88 • No. 3
March 2013

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activin

Cre-lox

Foxl2

gonadotroph

inhibin

LβT2

SMAD

transcription

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Daniel J. Bernard, Stella Tran "Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX," Biology of Reproduction, 88(3), (20 February 2013)

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