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20 February 2013 Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX
Daniel J. Bernard, Stella Tran
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Abstract

Activins were discovered and, in fact, named more than a quarter century ago based on their abilities to stimulate pituitary follicle-stimulating hormone (FSH) synthesis and secretion. However, it is only in the last decade that we have finally come to understand their underlying mechanisms of action in gonadotroph cells. In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.

Daniel J. Bernard and Stella Tran "Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX," Biology of Reproduction 88(3), (20 February 2013). https://doi.org/10.1095/biolreprod.113.107797
Received: 8 January 2013; Accepted: 1 February 2013; Published: 20 February 2013
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KEYWORDS
activin
Cre-lox
Foxl2
gonadotroph
inhibin
LβT2
SMAD
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