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7 August 2013 Trypsin Regulates Meiotic Initiation in the Japanese Eel ( Anguilla japonica) by Promoting the Uptake of Taurine into Germ Cells During Spermatogenesis
Masato Higuchi, Chiemi Miura, Toshiharu Iwai, Takeshi Miura
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Abstract

Meiosis is a unique and critical process in reproduction. Although the key molecular components of meiosis have been identified, the molecular mechanisms regulating the entry into this pathway remain unclear. We previously demonstrated that a progestin in teleost fish, 17alpha, 20beta-dihydroxy-4-pregnen-3-one, is essential for meiotic initiation, and up-regulates taurine synthesis and the production of trypsin in Sertoli cells. In the present study, we found that trypsin promotes the uptake of taurine into germ cells through the up-regulation of solute carrier family 6 (neurotransmitter transporter, taurine), member 6 (Slc6a6) expression. We further found that this up-regulation of the taurine signal is required for Spo11a expression and meiotic initiation.

Masato Higuchi, Chiemi Miura, Toshiharu Iwai, and Takeshi Miura "Trypsin Regulates Meiotic Initiation in the Japanese Eel ( Anguilla japonica) by Promoting the Uptake of Taurine into Germ Cells During Spermatogenesis," Biology of Reproduction 89(3), (7 August 2013). https://doi.org/10.1095/biolreprod.113.109777
Received: 1 April 2013; Accepted: 1 July 2013; Published: 7 August 2013
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KEYWORDS
meiosis
progesterone/progesterone receptor
spermatogenesis
taurine
trypsin
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