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22 July 2015 A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts
Ziyan Jiang, Yanfen Zou, Zhiping Ge, Qing Zuo, Shi Yun Huang, Lizhou Sun
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Abstract

Pre-eclampsia (PE) is a hypertensive disorder that occurs during pregnancy, and is a multifactorial disease. The antiangiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1), has been reported to be important in the pathogenesis of PE, but the mechanism of its involvement remains unknown. To test the effects of sFlt-1 on pregnancy, we injected pregnant mice with exogenous mouse sFlt-1. After 18 days of gestation, higher blood pressure, proteinuria, and histological differences were observed compared with controls. Mitochondrial swelling inside the trophoblast cells in the placenta of sFlt-1-treated pregnant mice was observed by electron microscopy, which suggested a role of sFlt-1 in oxidative stress in trophoblasts in PE. Furthermore, apoptosis markers were upregulated in sFlt-1-treated mice. In conclusion, sFlt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts. This may be an important mechanism in the development of PE.

Ziyan Jiang, Yanfen Zou, Zhiping Ge, Qing Zuo, Shi Yun Huang, and Lizhou Sun "A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts," Biology of Reproduction 93(3), (22 July 2015). https://doi.org/10.1095/biolreprod.114.126227
Received: 29 October 2014; Accepted: 1 July 2015; Published: 22 July 2015
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