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24 February 2016 New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification
Yanzhou Yang, Hoi Hung Cheung, Wai Nok Law, Cheng Zhang, Wai Yee Chan, Xiuying Pei, Yanrong Wang
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Abstract

Ovarian cryopreservation by vitrification is a highly useful method for preserving female fertility during radiotherapy and chemotherapy. However, cryoinjury, osmotic stress during vitrification, and ischemia/reperfusion during transplantation lead to loss of ovarian follicles. Ovarian follicle loss may be partially reduced by several methods; however, studies regarding the mechanism of ovarian follicle loss have only investigated cell apoptosis, which consists of type I programmed cell death. Autophagy is type II programmed cell death, and cell homeostasis is maintained by autophagy during conditions of stress. The role of autophagy during cryopreservation by vitrification has rarely been reported. The potential role of autophagy during ovarian cryopreservation by vitrification is reviewed in this article.

Yanzhou Yang, Hoi Hung Cheung, Wai Nok Law, Cheng Zhang, Wai Yee Chan, Xiuying Pei, and Yanrong Wang "New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification," Biology of Reproduction 94(6), (24 February 2016). https://doi.org/10.1095/biolreprod.115.136374
Received: 19 October 2015; Accepted: 1 February 2016; Published: 24 February 2016
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KEYWORDS
apoptosis,
atresia,
autophagy
cryobiology,
cryoinjury
cryopreservation,
ischemia/reperfusion
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