Several nuclear receptors have recently been identified as mediators of endocrine disruption as well as steroid hormone receptors. The ubiquitous environmental contaminant tributyltin chloride (TBT) is a ligand for retinoid X receptor (RXR) in rock shell at the nanomolar level, and it acts as a ligand for both the RXR and the peroxisome proliferator-activated receptor γin the frog Xenopus laevis and in humans. TBT, which induces imposex in marine snails and promotes adipogenesis in X. laevis and in mice, is an example of an environmental endocrine disrupter that promotes adverse effects, from the snail to mammals, through common signaling. In addition, juvenile hormone agonists used as pesticides showed endocrine-disruptive effects on parthenogenic Daphnia magna, lowering rates of reproduction, and inducing 100% male offspring. In this article, we focus on commonality in signaling through nuclear receptors and newly found endocrine disruption in D. magna.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.
Vol. 58 • No. 11