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1 May 2012 Rethinking the Origin of Chronic Diseases
Mohammadali M. Shoja, R. Shane Tubbs, Alireza Ghaffari, Marios Loukas, Paul S. Agutter
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Abstract

Since 1980, connections have been sought between chronic—especially autoimmune—diseases and possible microbial actions that might promote or suppress immune responses. Here, we propose that the pathogenesis of some chronic diseases is linked to ancestral infections or exposure to noxious agents: Some modern-day diseases reflect the capacity of organisms to “memorize” responses to external signals and transmit them across generations; the resulting information can be subsequently made functional under certain conditions, through stimulation by a relevant secondary influence. The proposal is supported by observations of transgenerational epigenetic inheritance. Therefore, autoimmune hepatitis (AIH) could be a recollection of our ancestors' long-term affliction with viral hepatitis; the original causative agent may not be extant today, but “memory” of the infection has persisted. A similar argument could apply to other chronic diseases. In this article, we discuss evidence supporting this idea, with an emphasis on the exemplar pair of viral hepatitis and AIH, and outline a mechanistic hypothesis.

© 2012 by American Institute of Biological Sciences. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjournals.com/reprintinfo.asp.
Mohammadali M. Shoja, R. Shane Tubbs, Alireza Ghaffari, Marios Loukas, and Paul S. Agutter "Rethinking the Origin of Chronic Diseases," BioScience 62(5), 470-478, (1 May 2012). https://doi.org/10.1525/bio.2012.62.5.8
Published: 1 May 2012
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KEYWORDS
ancestral infection
autoimmunity
chronic disease
Epigenetic inheritance
Toll-like receptor
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