In 1920, William Trelease published the name Agave panamana Trel. (Asparagaceae: Agavoideae / Agavaceae) based on material from Urava Island (Isla Urabá), Panama Bay, along the Pacific coast of Panama. This name is nowadays usually included in the synonymy of the very variable A. angustifolia Haw. [var. angustifolia]. A. panamana is here illustrated and its description comprehensively amplified to enable its comparison with A. angustifolia. Reference is made to the uses and considerable morphological variation found in A. angustifolia.