The objective of this study was to estimate economic losses associated with milk performance detriments under different climate scenarios. A dataset containing milk records of Holstein and daily temperature–humidity indexes compiled over 6 yr in two contrasting climatic dairy regions of Quebec [eastern (EQ) and southwestern Quebec (SWQ)] was used to develop equations for modeling milk performance. Milk performance, including milk, fat, protein, and lactose yields of dairy herds (kg·d⁻¹), were then projected considering six plausible climate scenarios during a climatic reference period (REF: 1971–2000) and two future periods (FUT1: 2020–2049; FUT2: 2050–2079). Economic losses were assessed by comparing future to reference milk prices based on components. Results indicated that fat and protein yields could decline in the future, thus resulting in economic losses ranging from $5.34 to $7.07 CAD·hL⁻¹ in EQ and from $5.03 to $6.99 CAD·hL⁻¹ in SWQ, depending on the amplitude of future temperature and humidity changes and on whether it is milk quota or cow number which is adjusted to avoid under-quota production. The projected increase in occurrence and duration of heat stress episodes under climate change could result in substantial financial harm for producers, thereby reinforcing the necessity of implementing heat-abatement strategies on dairy farms.