The objective of this study was to evaluate the use of barley (BS) or corn (CS) silage when fed with dry-rolled barley grain (BG), corn grain (CG), or an equal blend (BCG) of BG and CG for backgrounding cattle. Ruminally cannulated heifers (n = 5) were assigned to an incomplete 6 × 6 Latin square design. Treatments contained either BS or CS in combination with BG, CG, or BCG. Samples were collected to determine dry matter intake, ruminal fermentation, total-tract nutrient digestibility, and nitrogen (N) balance. Interactions between cereal silage and cereal grain sources were detected for the molar proportions of propionate and butyrate where the magnitude of change with the type of cereal grain was increased in heifers fed CS relative to BS. Feeding CS increased estimated microbial N production (silage, P = 0.022) and fecal N excretion (silage, P = 0.042) over BS. Diets containing BG had greater dry matter, organic matter, starch, and gross energy digestibility values compared with CG, but values for BCG were not different (grain, P ≤ 0.043). Based on limited silage × grain interactions, use of CS in backgrounding diets may increase microbial N production relative to BS and dry-rolled CG may reduce apparent total-tract nutrient digestibility relative to dry-rolled BG.