Effect of xylanase (Xyl) and live yeast (LY) supplementation on gut microbiome composition, growth performance, and nutrient digestibility of weanling pigs was determined. A total of 180 weanling pigs were assigned to five treatments from weaning to market. Treatments were designated based on whether Xyl, LY, or their combination were fed in the first 2 wk postweaning or thereafter until finishing at day 141 postweaning. Treatments were (days 1–15; days 15–141): control–control, control–Xyl, Xyl–Xyl, LY–Xyl, Xyl + LY–Xyl. Xylanase was added at 16 000 BXU·kg⁻¹ and LY at 1 kg·t⁻¹. Pigs fed with LY and LY + Xyl from days 0–15 had greater body weight and average daily gain at day 15 compared with control (P < 0.05). Glucose transporter 2 mRNA was higher in LY and LY + Xyl groups on day 15 compared with control (P < 0.05). Xylanase supplementation from week 2 postweaning increased apparent total tract nutrient digestibility of gross energy, nitrogen, and phosphorus on day 43. Live yeast with or without Xyl improved growth performance in the first 2 wk after weaning; Xyl + LY–Xyl and control–Xyl groups had improved overall feed efficiency. In conclusion, LY and Xyl supplementation improved performance of weanling pigs in the first 2 wk after weaning with no effects on long-term growth performance.