Le Thanh, B. V., Lessard, M., Chorfi, Y. and Guay, F. 2015. Short Communication: Antioxidant capacity in the intestinal mucosa of weanling piglets fed diets containing Fusarium mycotoxins and the efficacy of commercial supplements sold as detoxifiers. Can. J. Anim. Sci. 95: 569-575. The ability of commercial feed additives to prevent oxidative damage due to deoxynivalenol (DON) in piglets was studied. Sixty piglets (6.0±0.5 kg) were assigned randomly to six wheat-corn-soybean diets: control (<0.5 mg kg^-1 DON), DON-rich diet (4 mg kg^-1 DON), and four DON-rich diets supplemented with either glucomannan (DON GLUC), yeast, live bacteria, enzymes and plant extract (DON YBP), aluminosilicate (DON ALS), or a mixture of preservatives (DON PV). Malondialdehyde concentration (MDA), glutathione peroxidase activity (GPx), catalase activity (CAT) and superoxide dismutase activity (SOD) in the small intestine were measured after 14 d. The DON-rich diet increased MDA in the jejunum while decreasing CAT in the jejunum and SOD in the ileum and increasing GPx in the ileum (P<0.05). The DON GLUC diet decreased GPx and SOD (P<0.05) and tended to decrease MDA in the jejunum (P<0.10). The DON YBP, DON PV and DON ALS diets all decreased CAT in the jejunum, while DON YBP and DON PV also did so in the ileum (P<0.05). DON GLUC decreased SOD in the jejunum, while DON YBP increased it (P<0.05). In the ileum, DON PV decreased SOD, while DON ALS increased GPx (P<0.05). No significant differences in total antioxidant capacity (TAC) in intestinal tissues were found. This study demonstrates that the mycotoxin DON and anti-mycotoxin additives modify oxidative status, including the antioxidant enzyme activities (CAT, SOD or GPx) in the intestinal mucosa of piglets. However, it was not possible to identify a specific antioxidant enzyme involved in counteracting the effect of DON.