CDC Esme, a high-yielding, late-maturing oilseed flax (Linum usitatissimum L.) cultivar, was registered in 2023 by the Crop Development Centre, University of Saskatchewan, Saskatoon, Saskatchewan. CDC Esme had a superior yield (106%) compared to the check variety, CDC Glas, in all soil zones of the Northern Prairies. The yield of CDC Esme was 106%, 105%, and 105% of CDC Glas, in the long-season Black, Brown, and short-season Black and Grey soil zones of Western Canada, respectively. CDC Esme has larger seeds (thousand seed weight) than that of check cultivar, CDC Glas, with improved quality based on the iodine value of 192 and alpha-linolenic acid (ALA) content of 57.1%. This cultivar is immune to the North American rust (race 371) caused by Melampsora lini and moderately resistant to wilt caused by Fusarium oxysporum f. sp. lini.