Six field trials were conducted over a 2-yr period (2014 and 2015) at two locations in southwestern Ontario to compare the level of weed control provided by dicamba applied alone and in combination with dimethenamid-P applied before planting (preplant, PP) in glyphosate- and dicamba-resistant soybean to current industry standards when used in a two-pass weed management program. Crop injury, weed control, soybean seed yield, environmental impact (EI), and profitability were evaluated in this study. No statistically significant injury was documented. Several PP herbicides provided excellent early-season grass and broadleaf weed control, although early-season weed control of those weed species was not acceptable with glyphosate applied alone or in combination with dicamba, dicamba dimethenamid-P, 2,4-D, or saflufenacil. At 8 wk after application, the sequential application of a PP herbicide followed by glyphosate applied after emergence (POST) provided at least 86% control of the weed species evaluated in this study. Weed interference with no herbicide treatments caused a soybean seed yield loss of 64%. The sequential application of glyphosate had the lowest EI value. The addition of chlorimuron metribuzin or chlorimuron imazethapyr did not increase the EI substantially but did improve the level of weed control and reduced weed density and biomass. The inclusion of a PP herbicide in a weed management program has several stewardship benefits and may reduce the selection for herbicide resistant weeds.