Fourteen lizards representing 3 species within 2 families, Calumma brevicorne, Furcifer verrucosus, and Paroedura picta, from 3 sites in Madagascar were examined for helminths. Three helminths were recovered, including the cestode Oochoristica chavenoni in the small intestine of 1 of 7 (14%) P. picta; the physalopterid nematode Abbreviata madagascariensis in the stomach of 1 of 4 (25%) C. brevicorne and 2 of 3 (67%) Furcifer oustaleti; and the ascarid nematode Hexametra angusticaecoides in the small intestine of 1 of 3 (33%) F. oustaleti. It seems that Madagascar's lizard helminths have been isolated geographically and evolved independently from those on the African continent.