One-hundred trout-perch, Percopsis omiscomaycus, collected from Saginaw Bay, Lake Huron in September 2011, were examined for parasites. Seven parasite species (1 Myxozoa: Myxobolus procercum; 1 Ciliophora: Trichodina sp.; 3 Digenea: Allacanthochasmus sp., Neochasmus sp., Crepidostomum percopsisi; 1 Nematoda: Camallanus oxycephalus; 1 Copepoda: Ergasilus luciopercarum) were found to infect trout-perch. Crepidostomum percopsisi had the highest prevalence (98%), mean intensity (5.3), and mean abundance (5.2). Ergasilus luciopercarum had a prevalence of 46% and a mean intensity of 2.6. Myxobolus procercum and Allacanthochasmus sp.–Neochasmus sp. (considered 1 taxonomic group) each had a prevalence of 22%. Trichodina sp. and C. oxycephalus infrequently infected trout-perch. Gravid individuals of only C. percopsisi and E. luciopercarum were found. Trichodina sp., Allacanthochasmus sp., Neochasmus sp., C. oxycephalus, and E. luciopercarum are reported for the first time from trout-perch in Lake Huron.