Changes in soil fertility following long periods of crop production in the south-west of Western Australia (WA) may have implications for phosphorus (P) fertiliser recommendations for wheat production. When the sandy soils of the region were first cleared for agricultural production, they were typically marginally acidic to neutral, with soil extractable-P levels inadequate for crop production. Recent surveys have shown that 87% of soils in south-west WA exceed the critical soil extractable-P level required for 90% of maximum grain yield, and ∼70% of soils have a surface-soil pH_Ca <5.5. There has also been a shift towards a high frequency of wheat in the crop sequence. We conducted a field experiment to begin to quantify the importance of the interactions between soil pH and crop sequence on wheat response to P fertiliser. For grain yield, the magnitude of the response was greatest for rate of P applied, followed by lime treatment and then crop sequence. There were no interactions between these treatments. Our analysis of the grain-yield response to rates of P fertiliser showed no significant difference between the shape of the grain-yield response curve for treatments with and without lime. However, we did find a significant interaction between lime treatment and rate of P fertiliser applied for shoot P concentration and that soil P was more plant-available in the lime than the –lime treatment. There is justification for making realistic adjustments to yield potential based on soil pH or crop sequence, although further work is required to determine whether the shape of the grain-yield response curve varies with these two factors.