Floodplain wetlands in the upper Columbia River valley are governed by the flood pulse. Water flows from the river into adjacent wetlands through channels incised through levees or over the top of the levees. This floodplain is relatively pristine with few road crossings restricting the flow of water in a 110 km length of the floodplain. We describe the floodplain vegetation at three points over 60 years to detect natural vegetation changes and contrast that with changes downstream of roads transecting the wetlands. We mapped eight landscape cover types within 40 floodbasins and four 2 km sections downstream of road crossings at three dates, over 60 years, using historical aerial photographs. Over 60 years the area of open water increased by 77% within the wetlands, and there was a decrease of 14.5%and 40%of marsh and shrub vegetation, respectively. During this time, floodbasins became more connected to the river. We observed greater change within the natural wetlands than in sections downstream of the road crossings. Since floodplain ecosystems are inherently complex due to their highly dynamic nature, isolating specific causes of trends is difficult. However, large-scale loss of vegetation and increase in open water has dramatically changed the wetlands.