We discuss a group of four species from the Venezuelan Guayana, two of them closely related to Anathallis nanifolia (based on Pleurothallis nanifolia). These two species, Pleurothallis deborana and P. pemonum, were erroneously placed in the synonymy of Anathallis holstii (based on Pleurothallis holstii). We propose new combinations in Anathallis for these two species, discuss the current status of all four species, and provide a key to distinguish them.