Translator Disclaimer
1 June 2012 Distribution of the Lactase Persistence-Associated Variant Alleles -13910*T and -13915*G among the People of Oman and Yemen
Abdul Rahim Al-Abri, Omar Al-Rawas, Saeed Al-Yahyaee, Molham Al-Habori, Adel Sharaf Al-Zubairi, Riad Bayoumi
Author Affiliations +
Abstract

The high prevalence of lactase persistence (LP) among the people of Saudi Arabia is associated with the -13915*G variant allele upstream of the lactase gene (LCT). We, therefore, examined the frequency of the commonly known LP associated SNPs among randomly collected samples from Omani and Yemeni adult populations and obtained further data on the distribution of the two most common LP-associated variants, -13910*T and -13915T*G, in the Arabian Peninsula. The DNA fragment containing all the reported LP- associated SNPs was amplified and genotyped. The frequency of the -13915*G allele was highest among Dhofari Arabs of southern Oman (0.72) followed by Yemeni Arabs (0.54) and Arabs of northern Oman (0.14). It was not detected in Omanis of Asian origin. The frequency of the -13910*T allele was extremely low in Arabs of northern and southern Oman (0.00–0.01) and Yemenis (0.002). However, it had a frequency of 0.160 among Omanis of Asian origin. Results show that the highest frequency of the LCT -13915*G variant allele appears to be in the south of the Arabian Peninsula with clinal decrease within the Peninsula and further out in surrounding countries.

Copyright © 2012 Wayne State University Press, Detroit, Michigan 48201-1309.
Abdul Rahim Al-Abri, Omar Al-Rawas, Saeed Al-Yahyaee, Molham Al-Habori, Adel Sharaf Al-Zubairi, and Riad Bayoumi "Distribution of the Lactase Persistence-Associated Variant Alleles -13910*T and -13915*G among the People of Oman and Yemen," Human Biology 84(3), 271-286, (1 June 2012). https://doi.org/10.3378/027.084.0310
Received: 4 April 2012; Accepted: 15 May 2012; Published: 1 June 2012
JOURNAL ARTICLE
16 PAGES


Share
SHARE
KEYWORDS
Arabian Peninsula
LACTASE PERSISTENCE
Oman
YEMEN
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top