In March 2004, the U.S. Environmental Protection Agency (U.S. EPA) published a review of its risk assessment principles and practices. In examining this review, we find a broad, but not particularly deep, review by the authors and areas where the U.S. EPA should strive to further improve the risk assessment process. Recommended areas of improvement include the use of less conservative default assumptions, calculating risk based on populations instead of individuals, and fostering research on multiple stressors and their impacts on estimating risks to ecological receptors.