An integrative approach to investigate the species-level diversity in Oxynoe (Mollusca, Heterobranchia, Sacoglossa) revealed the existence of 11 distinct taxa. Oxynoe viridis (Pease, 1861) and Oxynoe antillarum Mörch, 1863 are redescribed; Oxynoe natalensis E. A. Smith, 1903 and Oxynoe azuropunctata Jensen, 1980 are regarded as valid. Species originally described from empty shells are regarded as nomina dubia. Seven new species are described, four from the tropical Indo-West Pacific: Oxynoe kylei, sp. nov., Oxynoe neridae, sp. nov., Oxynoe jordani, sp. nov. and Oxynoe jacksoni, sp. nov.; and two from the tropical Atlantic: Oxynoe struthioe, sp. nov. and Oxynoe ilani, sp. nov. The name Oxynoe panamensis Pilsbry & Olsson, 1943 has been applied to eastern Pacific specimens, but was introduced based on material collected from the Caribbean; therefore, the new name Oxynoe aliciae, sp. nov. is introduced for eastern Pacific specimens. Species are delineated using molecular and morphological traits, as well as algal host and reproductive biology. Results from morphological comparisons are concordant with molecular and integrative species delimitation analyses, providing robust evidence for species hypotheses. As Oxynoe is one of the few groups specialised to feed on the green algal genus Caulerpa, which includes highly invasive species, clarifying the taxonomy of Oxynoe may inform efforts to predict community response to disruptive algal invasions.