Information regarding pharmacokinetic disposition of drugs in ostriches (Struthio camelus) is very scarce. Three common veterinary nonsteroidal anti-inflammatory drugs (sodium salicylate, SA; flunixin, FLU; and meloxicam, MEL) were administered intravenously to young ostriches. Plasma concentrations of the drugs were determined by validated high-performance liquid chromatography methods and pharmacokinetic parameters were calculated. After intravenous administration of SA (25 mg/kg), FLU (1.1 mg/kg), and MEL (0.5 mg/kg), these drugs were eliminated from plasma with mean half-lives of 1.32, 0.17, and 0.5 hours, respectively. Apparent volumes of distribution (0.36 L/kg, 0.13 L/kg, and 0.58 L/kg, respectively) indicated that tissue distribution was limited for the 3 drugs. Total body clearance was 0.19 L/h·kg for SA and 0.50 and 0.72 L/kg·h for FLU and MEL, respectively. These nonsteroidal anti-inflammatory drugs, especially FLU and MEL, are rapidly cleared from the ostrich body.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.
Vol. 16 • No. 2