Trauma and skin defects are common presentations in companion and wild birds. Two barn owls (Tyto alba), an umbrella cockatoo (Cacatua alba), and an American crow (Corvus brachyrhynchos) were presented for varied skin wounds. Porcine small intestinal submucosa was used as a xenogeneic graft to repair wound defects in each bird. The wounds healed within 6 weeks in all 4 birds, with less intensive wound management than that required for healing by second intention. All birds returned to normal function.