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1 December 2009 Treatment of Nonepitheliotropic Cutaneous B-cell Lymphoma in an Umbrella Cockatoo (Cacatua alba)
Samuel Rivera, James R. McClearen, Drury R. Reavill
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A 3.5-year-old umbrella cockatoo (Cacatua alba) was presented because of the development of widely disseminated subcutaneous nodules. The diagnostic work-up included a complete blood count, plasma biochemical analysis, and whole body radiographs. Biopsy samples of the skin lesions were submitted for histopathologic evaluation, bacterial culture and sensitivity testing, immunohistochemistry staining, and acid-fast staining. The diagnosis was nonepitheliotropic cutaneous B-cell lymphoma with a leukemic blood picture. The bird was treated with a chemotherapeutic regimen consisting of vincristine and chlorambucil for 17 weeks. During treatment, the complete blood count was monitored every 1–3 weeks, and the plasma biochemical analysis was monitored every 3–4 weeks. The bird was in partial remission on week 9. On week 17, the bird became acutely ill and was fluffed, depressed, anorectic, and anemic. The chemotherapeutic regimen was discontinued. At this time, the bird had a consistent lymphocytosis but no neoplastic lymphocytes were seen in the general circulation. At week 29 the bird was in complete remission and remains in complete remission 8 years after chemotherapy was discontinued.

Samuel Rivera, James R. McClearen, and Drury R. Reavill "Treatment of Nonepitheliotropic Cutaneous B-cell Lymphoma in an Umbrella Cockatoo (Cacatua alba)," Journal of Avian Medicine and Surgery 23(4), 294-302, (1 December 2009).
Published: 1 December 2009
Cacatua alba
cutaneous lymphoma
umbrella cockatoo
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