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1 March 2018 Pharmacokinetics and Egg Residues of Meloxicam After Multiple Day Oral Dosing in Domestic Chickens
Marcy J. Souza, Joan Bailey, Molly White, Kristen Gordon, Lillian Gerhardt, Sherry K. Cox
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Abstract

With increased ownership of backyard poultry, veterinarians must treat these birds appropriately and take into consideration drug withdrawal times for eggs meant for consumption. Few studies have examined the pharmacokinetics or egg residues for medications commonly used in avian medicine. This study determined the pharmacokinetics of meloxicam in domestic chickens (n = 8) after oral dosing at 1 mg/kg q12h for a total of 9 doses (5 days). Additionally, the presence of meloxicam residues in eggs was determined. The terminal half-life, maximum concentration, and time to maximum concentration were 3.02 ± 1.15 hours, 7.14 ± 1.54 μg/mL, and 1.6 ± 0.52 hours, respectively. No drug was detected in yolks and whites after 8 days and 3 days, respectively. On the basis of these results, a 2-week withdrawal time should be adequate to avoid drug residues in eggs meant for consumption.

© 2018 by the Association of Avian Veterinarians
Marcy J. Souza, Joan Bailey, Molly White, Kristen Gordon, Lillian Gerhardt, and Sherry K. Cox "Pharmacokinetics and Egg Residues of Meloxicam After Multiple Day Oral Dosing in Domestic Chickens," Journal of Avian Medicine and Surgery 32(1), 8-12, (1 March 2018). https://doi.org/10.1647/22016-227
Published: 1 March 2018
JOURNAL ARTICLE
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