The sediment distribution in the southern Bay of Campeche is mainly governed by wind-induced currents and mesoscale cyclonic eddies. An increase in sediment grain size toward the sea is attributed to the presence of a convergence zone that sorts the sediments from heavier to lighter. A small anticyclonic eddy near the coast leads to a concentration of sediments westward of the Grijalva-Usumacinta River. We combined current profiles and charts of the distribution of magnetic susceptibility within sediments with a hydrodynamic numerical model to elucidate the distribution of the major sedimentary units in the Southern Bay of Campeche, Gulf of Mexico. Acoustic Doppler current profiles and geostrophic velocity data were used to set the water velocity at the open boundaries of the applied numerical model. The model was forced by the dominant winds. Sediment on the southeastern side of the bay is dominated by carbonates because of a lack of river discharge and other systems that contribute terrigenous sediments. In the southernmost side of the bay, where the major rivers are located, the bottom sediments are mainly of terrigenous origin.