Helicoverpa armigera sterol carrier protein-2 (HaSCP-2) is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera (Hübner). The discovery of chemical inhibitors of HaSCP-2 through a structure-based virtual screening is reported here. Bioassay indicated that H1 and H14 had inhibitory effect on the growth of H. armigera larvae. The results suggest that H1 and H14 are promising as useful lead compounds for further optimization and development of novel SCP-2-specific pesticides.
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12 June 2017
Identification of Potential Helicoverpa armigera (Lepidoptera: Noctuidae) Sterol Carrier Protein-2 Inhibitors Through High-Throughput Virtual Screening
Jun Cai,
Xinkai Du,
Changgao Wang,
Jianguo Lin,
Xin Du
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Journal of Economic Entomology
Vol. 110 • No. 4
July 2017
Vol. 110 • No. 4
July 2017
docking
inhibitor
insecticide
sterol carrier protein-2
virtual screening