The sweetpotato whitefly, Bemisia tabaci MEAM1 Gennadius, is a global pest of tomato, transmitting Tomato yellow leaf curl virus (TYLCV). Management of B. tabaci is challenging in part because of its ability to develop resistance to insecticides. Biopesticides include materials that control B. tabaci via mechanisms that do not select for resistance. Field experiments were conducted in the spring and fall of 2016 and 2017 at the University of Florida's Gulf Coast Research and Education Center in west central Florida to compare biopesticides to conventional insecticides for management of B. tabaci and TYLCV. Insecticide rotations were designed in part around the concept that conventional insecticide programs should group modes of action according to 5-wk treatment intervals, corresponding to an estimated 5-wk generation time for the pest. In 2016, when tomato was treated during the first 5-wk treatment interval with either biopesticides or neonicotinoid insecticides, insecticidal soap contributed to a reduction in whitefly egg numbers and percentageTYLCV that was comparable to results achieved with dinotefuran. In contrast, egg numbers and virus incidence in plants treated with kaolin clay tended to be numerically higher than the untreated control. In spring 2017, comparisons of biopesticides and conventional ovicides/nymphicides during the second 5-wk treatment interval showed that biopesticides can provide comparable reduction in nymph numbers to conventional insecticides. While data from these trials confirm that biopesticides can reduce numbers of whitefly eggs and nymphs, they indicate that season-long programs of the biopesticides evaluated may not reduce transmission of TYLCV below economically acceptable levels.