A 4-yr study was conducted comparing the efficacy and value of fungicide-only (FST), neonicotinoid insecticide + fungicide (NST), and diamide insecticide + fungicide (DST) seed treatments for commercial corn Zea mays L. and soybean Glycines max (L.) Merr. production in Ontario, Canada. Plant stand, plant vigor, above- and below-ground insect injury, and yield were assessed on 160 field-scale experiments. Experiments also assessed early-season insect incidence and abundance using newly legislated thresholds for NST use in Ontario and in-season destructive sampling.Wireworms (Coleoptera: Elateridae) and white grubs (Coleoptera: Scarabeidae) were frequently observed at experimental sites; however, thresholds were rarely met and injury levels rarely led to yield loss. Of 129 and 31 corn and soybean sites, 8 and 6%, respectively, had a positive yield response to NST use. Across all sites, yield response of 0.1 and –0.05 Mg ha^–1 was observed with NST use in corn and soybean, respectively; however, the costs associated with NST use were recovered at only 48 and 23% of corn and soybean sites, respectively, based on average grain prices and yields during the study. Infrequent incidence of economic injury and the absence of a consistent yield response to NST and DSTs throughout the 4 yr of the study indicate that widespread use of seed-applied insecticides in corn and soybean is unlikely to provide benefit to producers.These data highlight an opportunity for reducing input costs, environmental loading, and nontarget effects without adverse outcomes for Ontario producers.